Franchise 57 seasons 427–465–5 all-time 17 playoff trips 0 Super Bowls
1998 players
Passing
| Craig Whelihan | 320 | 149 | 1,803 | 8 | 19 | 5.6 |
| Ryan Leaf | 245 | 111 | 1,289 | 2 | 15 | 5.3 |
| Terrell Fletcher | 1 | 1 | 23 | 1 | 0 | 23.0 |
Rushing
| Natrone Means | 212 | 883 | 5 | 4.2 |
| Terrell Fletcher | 153 | 543 | 5 | 3.5 |
| Tremayne Stephens | 35 | 122 | 1 | 3.5 |
| Ryan Leaf | 27 | 80 | 0 | 3.0 |
| Charlie Jones | 4 | 39 | 0 | 9.8 |
| Craig Whelihan | 18 | 38 | 0 | 2.1 |
| Kenny Bynum | 11 | 23 | 0 | 2.1 |
Receiving
| Charlie Jones | 108 | 46 | 699 | 3 | 6.5 |
| Bryan Still | 81 | 43 | 605 | 2 | 7.5 |
| Freddie Jones | 112 | 57 | 602 | 3 | 5.4 |
| Mikhael Ricks | 85 | 30 | 450 | 2 | 5.3 |
| Ryan Thelwell | 37 | 16 | 268 | 1 | 7.2 |
| Terrell Fletcher | 43 | 30 | 188 | 0 | 4.4 |
| Webster Slaughter | 24 | 8 | 93 | 0 | 3.9 |
| Natrone Means | 22 | 16 | 91 | 0 | 4.1 |
| John Burke | 5 | 3 | 32 | 0 | 6.4 |
| Frank Hartley | 4 | 2 | 28 | 0 | 7.0 |
| Kenny Bynum | 5 | 4 | 27 | 0 | 5.4 |
| Wendell Davis | 5 | 4 | 23 | 0 | 4.6 |
| Tremayne Stephens | 6 | 2 | 9 | 0 | 1.5 |
Defense
| Junior Seau | RLB | 115 | 92 | 3.5 | 0 | 2 |
| Rodney Harrison | SS | 114 | 89 | 4.0 | 3 | 2 |
| Charles Dimry | LCB | 63 | 59 | 0.0 | 3 | 1 |
| Greg Jackson | FS | 59 | 50 | 0.0 | 6 | 0 |
| Marco Coleman | RDE | 51 | 46 | 3.5 | 0 | 0 |
| Norman Hand | LDT | 49 | 42 | 6.0 | 2 | 2 |
| Kurt Gouveia | MLB | 44 | 32 | 0.5 | 0 | 0 |
| Terrance Shaw | RCB | 40 | 35 | 0.0 | 2 | 0 |
| John Parrella | RDT | 37 | 30 | 1.5 | 0 | 0 |
| Gerald Dixon | LLB | 34 | 26 | 2.5 | 0 | 0 |
| Jimmy Spencer | DB | 29 | 29 | 0.0 | 1 | 0 |
| Steve Tovar | LB | 28 | 22 | 1.0 | 0 | 0 |
| William Fuller | LDE | 22 | 18 | 3.0 | 0 | 0 |
| Lewis Bush | LLB | 18 | 12 | 1.0 | 0 | 1 |
| Mike Dumas | DB | 11 | 8 | 1.0 | 0 | 0 |
| Dwayne Harper | DB | 8 | 5 | 0.0 | 1 | 0 |
| Gerome Williams | DB | 8 | 7 | 0.0 | 0 | 0 |
| Scott Turner | DB | 7 | 7 | 1.0 | 1 | 1 |
| Chris Mims | DE | 6 | 3 | 2.0 | 0 | 0 |
| Jamal Williams | DT | 6 | 5 | 0.0 | 1 | 0 |
| Mike Mohring | DT | 3 | 2 | 1.0 | 0 | 0 |
| James Burgess | LB | 2 | 1 | 0.0 | 0 | 0 |
| Willie Clark | DB | 1 | 1 | 0.0 | 0 | 0 |
| Michael Hamilton | LB | 1 | 1 | 0.0 | 0 | 0 |
| Raylee Johnson | DE | 0 | 0 | 5.5 | 0 | 1 |