Franchise 57 seasons 446–445–6 all-time 20 playoff trips 3 Super Bowls
2001 players
Passing
| Rich Gannon | 549 | 361 | 3,828 | 27 | 9 | 7.0 |
| Marques Tuiasosopo | 4 | 3 | 34 | 0 | 0 | 8.5 |
Rushing
| Charlie Garner | 211 | 839 | 1 | 4.0 |
| Tyrone Wheatley | 88 | 276 | 5 | 3.1 |
| Rich Gannon | 63 | 231 | 2 | 3.7 |
| Zack Crockett | 57 | 145 | 6 | 2.5 |
| Randy Jordan | 13 | 59 | 0 | 4.5 |
| Terry Kirby | 10 | 49 | 0 | 4.9 |
| Tim Brown | 4 | 39 | 0 | 9.8 |
| Jerry Porter | 2 | 13 | 0 | 6.5 |
| Shane Lechler | 1 | 2 | 0 | 2.0 |
| Marques Tuiasosopo | 1 | 1 | 0 | 1.0 |
Receiving
| Tim Brown | 140 | 91 | 1,165 | 9 | 8.3 |
| Jerry Rice | 125 | 83 | 1,139 | 9 | 9.1 |
| Charlie Garner | 91 | 72 | 578 | 2 | 6.4 |
| Roland Williams | 53 | 33 | 298 | 3 | 5.6 |
| Jerry Porter | 37 | 19 | 220 | 0 | 5.9 |
| Jon Ritchie | 27 | 19 | 154 | 2 | 5.7 |
| Jeremy Brigham | 17 | 12 | 85 | 1 | 5.0 |
| Randy Jordan | 15 | 9 | 63 | 0 | 4.2 |
| Terry Kirby | 9 | 9 | 62 | 0 | 6.9 |
| Tyrone Wheatley | 16 | 12 | 61 | 1 | 3.8 |
| James Jett | 3 | 2 | 19 | 0 | 6.3 |
| Jermaine Williams | 3 | 2 | 11 | 0 | 3.7 |
| Zack Crockett | 3 | 2 | 10 | 0 | 3.3 |
| David Dunn | 1 | 1 | 8 | 0 | 8.0 |