Franchise 77 seasons 609–519–14 all-time 30 playoff trips 5 Super Bowls
1979 players
Passing
| Steve DeBerg | 578 | 347 | 3,652 | 17 | 21 | 6.3 |
| Joe Montana | 23 | 13 | 96 | 1 | 0 | 4.2 |
| Freddie Solomon | 1 | 1 | 12 | 0 | 0 | 12.0 |
Rushing
| Paul Hofer | 123 | 615 | 7 | 5.0 |
| O.J. Simpson | 120 | 460 | 3 | 3.8 |
| Wilbur Jackson | 114 | 375 | 2 | 3.3 |
| Lenvil Elliott | 33 | 135 | 3 | 4.1 |
| Phil Francis | 31 | 118 | 1 | 3.8 |
| Freddie Solomon | 6 | 85 | 1 | 14.2 |
| James Owens | 7 | 33 | 0 | 4.7 |
| Bob Ferrell | 8 | 33 | 0 | 4.1 |
| Mike Hogan | 9 | 31 | 0 | 3.4 |
| Joe Montana | 3 | 22 | 0 | 7.3 |
| Mike Shumann | 1 | 19 | 0 | 19.0 |
| Steve DeBerg | 17 | 10 | 0 | 0.6 |
| Dan Melville | 3 | 0 | 0 | 0.0 |
| Bob Bruer | 5 | -4 | 0 | -0.8 |
Receiving
| Freddie Solomon | 98 | 57 | 807 | 7 | 8.2 |
| Paul Hofer | 88 | 58 | 662 | 2 | 7.5 |
| Mike Shumann | 69 | 39 | 452 | 4 | 6.6 |
| Wilbur Jackson | 75 | 53 | 422 | 0 | 5.6 |
| Ken MacAfee | 38 | 24 | 266 | 4 | 7.0 |
| Bob Bruer | 39 | 26 | 254 | 1 | 6.5 |
| Dwight Clark | 28 | 18 | 232 | 0 | 8.3 |
| Phil Francis | 47 | 32 | 198 | 0 | 4.2 |
| Lenvil Elliott | 37 | 23 | 197 | 0 | 5.3 |
| James Owens | 20 | 10 | 121 | 0 | 6.0 |
| Terry LeCount | 17 | 6 | 119 | 2 | 7.0 |
| Mike Hogan | 10 | 9 | 65 | 0 | 6.5 |
| O.J. Simpson | 13 | 7 | 46 | 0 | 3.5 |
| Paul Seal | 9 | 3 | 34 | 0 | 3.8 |
| Bob Ferrell | 3 | 2 | 4 | 0 | 1.3 |
Defense
| Tom Seabron | LB | 1.0 | 0 | 0 |
| Dwaine Board | RDE | 7.0 | 0 | 1 |
| Dan Bunz | MLB | 1.0 | 1 | 1 |
| Al Cowlings | DE | 1.0 | 0 | 0 |
| Cedrick Hardman | RDE | 3.0 | 0 | 1 |
| Willie Harper | RLB | 1.0 | 0 | 2 |
| Archie Reese | LDE | 5.0 | 0 | 0 |
| Ron Shumon | LB | 1.0 | 0 | 0 |
| Ted Vincent | LDT | 6.0 | 0 | 1 |
| Jimmy Webb | RDT | 4.0 | 0 | 2 |