Franchise 77 seasons 609–519–14 all-time 30 playoff trips 5 Super Bowls
2026 players
Passing
| Brock Purdy | 142 | 98 | 1,196 | 13 | 2 | 8.4 |
Rushing
| Christian McCaffrey | 61 | 286 | 5 | 4.7 |
| Kaelon Black | 37 | 136 | 0 | 3.7 |
| Brock Purdy | 25 | 128 | 1 | 5.1 |
| Deebo Samuel Sr. | 9 | 78 | 0 | 8.7 |
| Jordan James | 4 | 15 | 0 | 3.8 |
| Jacob Cowing | 1 | 2 | 0 | 2.0 |
| Mac Jones | 2 | -2 | 0 | -1.0 |
Receiving
| Mike Evans | 34 | 24 | 326 | 3 | 9.6 |
| George Kittle | 28 | 21 | 268 | 4 | 9.6 |
| Deebo Samuel Sr. | 20 | 16 | 206 | 3 | 10.3 |
| Christian McCaffrey | 25 | 19 | 137 | 0 | 5.5 |
| Demarcus Robinson | 6 | 5 | 84 | 1 | 14.0 |
| Jordan Watkins | 2 | 2 | 60 | 0 | 30.0 |
| Kyle Juszczyk | 6 | 4 | 55 | 1 | 9.2 |
| Luke Farrell | 4 | 2 | 19 | 0 | 4.8 |
| KhaDarel Hodge | 1 | 1 | 18 | 0 | 18.0 |
| Jacob Cowing | 5 | 1 | 9 | 0 | 1.8 |
| Brandin Cooks | 3 | 1 | 7 | 1 | 2.3 |
| Kaelon Black | 2 | 1 | 5 | 0 | 2.5 |
| Jake Brendel | 1 | 1 | 2 | 0 | 2.0 |
Defense
| Fred Warner | MLB | 50 | 22 | 0.5 | 0 | 3 | 3 |
| Dre Greenlaw | LB | 37 | 18 | 0.0 | 0 | 0 | 1 |
| Ji'Ayir Brown | SAF | 34 | 17 | 0.0 | 0 | 2 | 0 |
| Marques Sigle | SAF | 26 | 13 | 1.0 | 0 | 0 | 0 |
| Renardo Green | CB | 22 | 14 | 0.0 | 3 | 5 | 0 |
| Deommodore Lenoir | CB | 21 | 12 | 0.0 | 0 | 1 | 0 |
| Jaden Dugger | LB | 17 | 10 | 1.0 | 0 | 0 | 0 |
| Malik Mustapha | SAF | 16 | 9 | 0.0 | 0 | 2 | 0 |
| Upton Stout | CB | 16 | 9 | 0.5 | 0 | 1 | 0 |
| Gracen Halton | DT | 14 | 8 | 1.0 | 0 | 1 | 1 |
| Keion White | DE | 9 | 5 | 3.0 | 0 | 0 | 0 |
| Osa Odighizuwa | DT | 9 | 3 | 1.0 | 0 | 1 | 0 |
| Khalid Kareem | DE | 8 | 5 | 0.0 | 0 | 0 | 0 |
| Sebastian Valdez | DT | 8 | 4 | 1.0 | 0 | 0 | 0 |
| Nick Bosa | DE | 7 | 3 | 0.0 | 0 | 0 | 0 |
| Garret Wallow | LB | 7 | 5 | 0.0 | 0 | 0 | 0 |
| Luke Gifford | LB | 6 | 3 | 0.0 | 0 | 0 | 0 |
| Ashtyn Davis | SAF | 6 | 1 | 0.0 | 0 | 0 | 0 |
| Brayden Willis | TE | 6 | 1 | 0.0 | 0 | 0 | 0 |
| Jack Jones | CB | 6 | 4 | 0.0 | 0 | 3 | 0 |
| Luke Farrell | TE | 6 | 3 | 0.0 | 0 | 0 | 1 |
| C.J. West | DT | 5 | 1 | 0.0 | 0 | 0 | 0 |
| KhaDarel Hodge | WR | 5 | 3 | 0.0 | 0 | 0 | 0 |
| Siran Neal | DB | 4 | 4 | 0.0 | 0 | 0 | 2 |
| James Thompson Jr. | DT | 4 | 1 | 0.0 | 0 | 0 | 0 |
| Romello Height | DE | 3 | 3 | 1.0 | 0 | 0 | 0 |
| Mykel Williams | DE | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Naquan Jones | DT | 2 | 0 | 0.0 | 0 | 0 | 0 |
| Ogbo Okoronkwo | DE | 2 | 2 | 1.0 | 0 | 0 | 0 |
| George Kittle | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Matthew Judon | OLB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Kevin Givens | DT | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Colton McKivitz | OT | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Jordan James | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Connor Colby | G | 1 | 1 | 0.0 | 0 | 0 | 0 |