Franchise 77 seasons 609–519–14 all-time 30 playoff trips 5 Super Bowls
1985 players
Passing
| Joe Montana | 494 | 303 | 3,653 | 27 | 13 | 7.4 |
| Matt Cavanaugh | 54 | 28 | 334 | 1 | 1 | 6.2 |
| Derrick Harmon | 1 | 0 | 0 | 0 | 0 | 0.0 |
| Freddie Solomon | 1 | 0 | 0 | 0 | 0 | 0.0 |
Rushing
| Roger Craig | 214 | 1,050 | 9 | 4.9 |
| Wendell Tyler | 171 | 867 | 6 | 5.1 |
| Joe Montana | 42 | 153 | 3 | 3.6 |
| Derrick Harmon | 28 | 92 | 0 | 3.3 |
| Jerry Rice | 6 | 26 | 1 | 4.3 |
| Bill Ring | 8 | 23 | 1 | 2.9 |
| Earl Cooper | 2 | 12 | 0 | 6.0 |
| Matt Cavanaugh | 4 | 5 | 0 | 1.2 |
| Freddie Solomon | 2 | 4 | 0 | 2.0 |
Receiving
| Roger Craig | 117 | 92 | 1,016 | 6 | 8.7 |
| Jerry Rice | 98 | 49 | 927 | 3 | 9.5 |
| Dwight Clark | 94 | 54 | 705 | 10 | 7.5 |
| Russ Francis | 56 | 44 | 478 | 3 | 8.5 |
| Freddie Solomon | 48 | 25 | 259 | 1 | 5.4 |
| Mike Wilson | 19 | 10 | 165 | 2 | 8.7 |
| Wendell Tyler | 31 | 20 | 154 | 2 | 5.0 |
| Derrick Harmon | 22 | 14 | 123 | 0 | 5.6 |
| Carl Monroe | 21 | 10 | 51 | 0 | 2.4 |
| John Frank | 16 | 7 | 50 | 1 | 3.1 |
| Earl Cooper | 15 | 4 | 45 | 0 | 3.0 |
| Bill Ring | 2 | 2 | 14 | 0 | 7.0 |
Defense
| Ronnie Lott | LCB/FS | 104 | 104 | 1.5 | 6 | 1 |
| Mike Walter | RILB | 0 | 0 | 3.0 | 1 | 1 |
| Dwaine Board | RDE | 0 | 0 | 11.5 | 0 | 3 |
| Michael Carter | NT | 0 | 0 | 7.0 | 0 | 2 |
| Fred Dean | DE | 0 | 0 | 3.0 | 0 | 2 |
| Riki Ellison | LILB | 0 | 0 | 1.0 | 0 | 0 |
| Jeff Fuller | DB | 0 | 0 | 2.0 | 1 | 2 |
| Scott Garnett | NT | 0 | 0 | 2.0 | 0 | 1 |
| Dwight Hicks | FS/LCB | 0 | 0 | 1.0 | 4 | 1 |
| Gary Johnson | DE | 0 | 0 | 4.0 | 0 | 1 |
| Jim Kovach | LB | 0 | 0 | 1.0 | 1 | 0 |
| Todd Shell | LOLB | 0 | 0 | 4.0 | 1 | 0 |
| Jeff Stover | LDE | 0 | 0 | 10.0 | 0 | 0 |
| Jim Stuckey | DE | 0 | 0 | 2.0 | 0 | 2 |
| Manu Tuiasosopo | NT | 0 | 0 | 3.0 | 0 | 0 |
| Keena Turner | ROLB | 0 | 0 | 6.0 | 0 | 1 |