Franchise 77 seasons 609–519–14 all-time 30 playoff trips 5 Super Bowls
2001 players
Passing
| Jeff Garcia | 504 | 316 | 3,538 | 32 | 12 | 7.0 |
| Tim Rattay | 2 | 2 | 21 | 0 | 0 | 10.5 |
Rushing
| Garrison Hearst | 252 | 1,206 | 4 | 4.8 |
| Kevan Barlow | 125 | 512 | 4 | 4.1 |
| Jeff Garcia | 72 | 254 | 5 | 3.5 |
| Terry Jackson | 22 | 138 | 1 | 6.3 |
| Fred Beasley | 23 | 73 | 1 | 3.2 |
| Paul Smith | 4 | 27 | 1 | 6.8 |
| Terrell Owens | 4 | 21 | 0 | 5.2 |
| Vinny Sutherland | 1 | 16 | 0 | 16.0 |
| Jason Baker | 1 | 0 | 0 | 0.0 |
| Tim Rattay | 5 | -3 | 0 | -0.6 |
Receiving
| Terrell Owens | 155 | 93 | 1,412 | 16 | 9.1 |
| J.J. Stokes | 90 | 54 | 585 | 7 | 6.5 |
| Eric Johnson | 64 | 40 | 362 | 3 | 5.7 |
| Garrison Hearst | 55 | 41 | 347 | 1 | 6.3 |
| Tai Streets | 52 | 28 | 345 | 1 | 6.6 |
| Kevan Barlow | 28 | 22 | 247 | 1 | 8.8 |
| Fred Beasley | 28 | 16 | 99 | 0 | 3.5 |
| Terry Jackson | 14 | 12 | 91 | 2 | 6.5 |
| Justin Swift | 11 | 11 | 66 | 1 | 6.0 |
| Vinny Sutherland | 1 | 1 | 5 | 0 | 5.0 |
Defense
| Derek M. Smith | ILB | 85 | 55 | 3.0 | 1 | 3 | 0 |
| Jeff Ulbrich | ILB | 74 | 50 | 0.5 | 0 | 1 | 1 |
| Jason Webster | DB | 65 | 57 | 0.5 | 3 | 10 | 1 |
| Zack Bronson | DB | 54 | 48 | 0.0 | 7 | 13 | 0 |
| Ahmed Plummer | CB | 51 | 45 | 0.0 | 7 | 18 | 0 |
| Rashad Holman | CB | 48 | 42 | 0.0 | 1 | 2 | 0 |
| Lance Schulters | S | 47 | 38 | 1.0 | 3 | 10 | 0 |
| Jamie Winborn | OLB | 45 | 32 | 0.5 | 2 | 3 | 0 |
| Julian Peterson | OLB | 43 | 29 | 3.0 | 0 | 3 | 0 |
| Andre Carter | DE | 42 | 35 | 6.5 | 0 | 4 | 2 |
| Bryant Young | DT | 35 | 29 | 3.5 | 0 | 1 | 1 |
| Ronnie Heard | FS | 34 | 26 | 1.0 | 0 | 2 | 3 |
| Dana Stubblefield | DT | 29 | 22 | 4.0 | 0 | 1 | 1 |
| Chike Okeafor | OLB | 27 | 17 | 2.5 | 0 | 2 | 1 |
| John Engelberger | DE | 25 | 24 | 4.0 | 0 | 5 | 4 |
| Terry Killens | LB | 22 | 19 | 0.0 | 0 | 0 | 0 |
| George McCullough | DB | 18 | 16 | 0.0 | 0 | 1 | 1 |
| Terry Jackson | RB | 12 | 9 | 0.0 | 0 | 0 | 1 |
| Anthony Parker | DB | 10 | 8 | 0.0 | 0 | 1 | 0 |
| Bobby Setzer | DE | 8 | 6 | 1.0 | 0 | 0 | 1 |
| Paul Smith | RB | 7 | 7 | 0.0 | 0 | 0 | 1 |
| Jimmy Williams | DB | 6 | 5 | 0.0 | 0 | 0 | 0 |
| Jose Cortez | K | 6 | 5 | 0.0 | 0 | 0 | 0 |
| John Schlecht | DT | 6 | 4 | 0.0 | 0 | 0 | 0 |
| Terrell Owens | WR | 5 | 4 | 0.0 | 0 | 0 | 1 |
| Quincy Stewart | LB | 4 | 4 | 0.0 | 0 | 0 | 0 |
| Reggie McGrew | DT | 4 | 4 | 1.0 | 0 | 2 | 0 |
| Brian Jennings | LS | 4 | 3 | 0.0 | 0 | 0 | 0 |
| Jason Baker | P | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Tyronne Drakeford | CB | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Justin Swift | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Kevan Barlow | RB | 2 | 2 | 0.0 | 0 | 0 | 1 |
| Jonas Lewis | RB | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Dave Fiore | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Ray Brown | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Scott Gragg | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Jeff Garcia | QB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Jeremy Newberry | C | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Eric Johnson | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |