Franchise 77 seasons 609–519–14 all-time 30 playoff trips 5 Super Bowls
2003 players
Passing
| Jeff Garcia | 392 | 225 | 2,704 | 18 | 13 | 6.9 |
| Tim Rattay | 118 | 73 | 856 | 7 | 2 | 7.3 |
| Cedrick Wilson | 1 | 1 | 6 | 0 | 0 | 6.0 |
Rushing
| Kevan Barlow | 201 | 1,024 | 6 | 5.1 |
| Garrison Hearst | 178 | 768 | 3 | 4.3 |
| Jeff Garcia | 54 | 325 | 7 | 6.0 |
| Jamal Robertson | 32 | 136 | 0 | 4.2 |
| Fred Beasley | 17 | 24 | 0 | 1.4 |
| Arnaz Battle | 2 | 14 | 0 | 7.0 |
| Bill Lafleur | 1 | 0 | 0 | 0.0 |
| Tim Rattay | 8 | 0 | 0 | 0.0 |
| Terrell Owens | 3 | -2 | 0 | -0.7 |
| Cedrick Wilson | 1 | -4 | 0 | -4.0 |
Receiving
| Terrell Owens | 80 | 1,102 | 9 | 13.8 |
| Tai Streets | 47 | 595 | 7 | 12.7 |
| Jed Weaver | 35 | 437 | 1 | 12.5 |
| Cedrick Wilson | 35 | 396 | 2 | 11.3 |
| Kevan Barlow | 35 | 307 | 1 | 8.8 |
| Brandon Lloyd | 14 | 212 | 2 | 15.1 |
| Garrison Hearst | 25 | 211 | 1 | 8.4 |
| Fred Beasley | 19 | 184 | 1 | 9.7 |
| Aaron Walker | 8 | 116 | 1 | 14.5 |
| Jeff Garcia | 1 | 6 | 0 | 6.0 |
Defense
| Derek M. Smith | ILB | 94 | 67 | 3.5 | 0 | 3 | 1 |
| Julian Peterson | OLB | 82 | 57 | 5.5 | 2 | 12 | 2 |
| Jeff Ulbrich | ILB | 73 | 52 | 3.5 | 1 | 5 | 1 |
| Tony Parrish | S | 69 | 52 | 0.5 | 9 | 18 | 1 |
| Ahmed Plummer | CB | 62 | 54 | 0.0 | 4 | 16 | 0 |
| Mike Rumph | DB | 60 | 51 | 2.0 | 3 | 7 | 1 |
| Zack Bronson | DB | 38 | 33 | 0.0 | 1 | 2 | 0 |
| Travis Kirschke | DE | 33 | 23 | 1.5 | 0 | 0 | 0 |
| Bryant Young | DT | 33 | 26 | 4.0 | 0 | 4 | 1 |
| Andre Carter | DE | 32 | 25 | 6.5 | 0 | 3 | 1 |
| Jamie Winborn | OLB | 29 | 26 | 3.0 | 0 | 2 | 1 |
| Dwaine Carpenter | DB | 27 | 24 | 0.0 | 0 | 3 | 3 |
| John Engelberger | DE | 26 | 23 | 4.5 | 0 | 1 | 1 |
| Chidi Ahanotu | DT | 22 | 16 | 4.0 | 0 | 2 | 0 |
| Jimmy Williams | DB | 22 | 20 | 0.0 | 1 | 1 | 1 |
| Anthony Adams | DT | 21 | 15 | 1.5 | 0 | 4 | 0 |
| Rashad Holman | CB | 21 | 16 | 0.0 | 0 | 2 | 0 |
| Terry Jackson | RB | 18 | 14 | 0.0 | 0 | 0 | 0 |
| Sean Moran | DE | 15 | 12 | 1.5 | 0 | 0 | 0 |
| John Keith | DB | 14 | 9 | 0.0 | 0 | 0 | 0 |
| Saleem Rasheed | LB | 11 | 5 | 0.0 | 0 | 1 | 1 |
| Ronnie Heard | FS | 10 | 6 | 0.5 | 1 | 1 | 0 |
| Brandon Moore | LB | 9 | 8 | 0.0 | 0 | 0 | 0 |
| Jason Webster | DB | 9 | 6 | 0.0 | 1 | 3 | 0 |
| Jed Weaver | TE | 6 | 6 | 0.0 | 0 | 0 | 0 |
| Arnaz Battle | WR | 5 | 5 | 0.0 | 0 | 0 | 0 |
| Cornelius Anthony | LB | 4 | 3 | 0.0 | 0 | 0 | 0 |
| Tai Streets | WR | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Jeremy Newberry | C | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Jamal Robertson | RB | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Terrell Owens | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Jeff Garcia | QB | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Brian Jennings | LS | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Derrick Deese | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Garrison Hearst | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Scott Gragg | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Ron Stone | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| James Jordan | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| DeVone Claybrooks | DT | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Kevan Barlow | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Cedrick Wilson | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Kyle Kosier | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Andrew Williams | DE | 1 | 1 | 0.0 | 0 | 0 | 0 |