Franchise 77 seasons 609–519–14 all-time 30 playoff trips 5 Super Bowls
2005 players
Passing
| Alex Smith | 165 | 84 | 875 | 1 | 11 | 5.3 |
| Tim Rattay | 97 | 56 | 667 | 5 | 6 | 6.9 |
| Ken Dorsey | 90 | 48 | 481 | 2 | 2 | 5.3 |
| Cody Pickett | 35 | 14 | 140 | 0 | 2 | 4.0 |
| Arnaz Battle | 2 | 2 | 27 | 0 | 0 | 13.5 |
Rushing
| Frank Gore | 127 | 608 | 3 | 4.8 |
| Kevan Barlow | 176 | 581 | 3 | 3.3 |
| Maurice Hicks | 59 | 308 | 3 | 5.2 |
| Alex Smith | 30 | 103 | 0 | 3.4 |
| Cody Pickett | 13 | 42 | 0 | 3.2 |
| Tim Rattay | 7 | 18 | 0 | 2.6 |
| Terry Jackson | 2 | 11 | 0 | 5.5 |
| Arnaz Battle | 8 | 11 | 0 | 1.4 |
| Ken Dorsey | 4 | 11 | 0 | 2.8 |
| Chris Hetherington | 1 | 3 | 0 | 3.0 |
| Rasheed Marshall | 1 | -7 | 0 | -7.0 |
Receiving
| Brandon Lloyd | 48 | 733 | 5 | 15.3 |
| Arnaz Battle | 32 | 363 | 3 | 11.3 |
| Johnnie Morton | 21 | 288 | 0 | 13.7 |
| Kevan Barlow | 31 | 241 | 0 | 7.8 |
| Frank Gore | 15 | 131 | 0 | 8.7 |
| Jason McAddley | 7 | 125 | 0 | 17.9 |
| Terry Jones | 9 | 76 | 0 | 8.4 |
| Terry Jackson | 10 | 67 | 0 | 6.7 |
| Billy Bajema | 5 | 54 | 0 | 10.8 |
| Maurice Hicks | 12 | 47 | 0 | 3.9 |
| Chris Hetherington | 5 | 26 | 0 | 5.2 |
| Steve Bush | 3 | 21 | 0 | 7.0 |
| Fred Beasley | 2 | 12 | 0 | 6.0 |
| Trent Smith | 3 | 7 | 0 | 2.3 |
| Rasheed Marshall | 1 | -1 | 0 | -1.0 |