Franchise 77 seasons 609–519–14 all-time 30 playoff trips 5 Super Bowls
2010 players
Passing
| Alex Smith | 342 | 204 | 2,370 | 14 | 10 | 6.9 |
| Troy Smith | 145 | 73 | 1,176 | 5 | 4 | 8.1 |
| David Carr | 13 | 5 | 67 | 0 | 1 | 5.2 |
Rushing
| Frank Gore | 203 | 853 | 3 | 4.2 |
| Brian Westbrook | 77 | 340 | 4 | 4.4 |
| Anthony Dixon | 70 | 237 | 2 | 3.4 |
| Troy Smith | 23 | 121 | 1 | 5.3 |
| Alex Smith | 18 | 60 | 0 | 3.3 |
| Delanie Walker | 3 | 18 | 0 | 6.0 |
| Josh Morgan | 2 | 17 | 0 | 8.5 |
| Ted Ginn | 2 | 11 | 0 | 5.5 |
| Moran Norris | 3 | 0 | 0 | 0.0 |
Receiving
| Vernon Davis | 93 | 56 | 914 | 7 | 9.8 |
| Michael Crabtree | 101 | 55 | 741 | 6 | 7.3 |
| Josh Morgan | 80 | 44 | 698 | 2 | 8.7 |
| Frank Gore | 72 | 46 | 452 | 2 | 6.3 |
| Delanie Walker | 45 | 29 | 331 | 0 | 7.4 |
| Ted Ginn | 35 | 12 | 163 | 1 | 4.7 |
| Brian Westbrook | 24 | 16 | 150 | 1 | 6.2 |
| Dominique Zeigler | 15 | 9 | 98 | 0 | 6.5 |
| Nate Byham | 7 | 5 | 27 | 0 | 3.9 |
| Moran Norris | 9 | 4 | 20 | 0 | 2.2 |
| Anthony Dixon | 5 | 5 | 11 | 0 | 2.2 |
| Kyle Williams | 1 | 1 | 8 | 0 | 8.0 |
Defense
| Patrick Willis | ILB | 119 | 92 | 6.0 | 0 | 5 | 2 |
| Takeo Spikes | ILB | 96 | 69 | 0.0 | 3 | 9 | 0 |
| Nate Clements | S | 78 | 68 | 1.0 | 3 | 10 | 3 |
| Dashon Goldson | DB | 72 | 55 | 1.0 | 1 | 6 | 0 |
| Justin Smith | DE | 64 | 51 | 8.5 | 0 | 1 | 1 |
| Manny Lawson | OLB | 54 | 43 | 2.5 | 1 | 6 | 2 |
| NaVorro Bowman | MLB | 44 | 36 | 0.0 | 0 | 0 | 0 |
| Shawntae Spencer | CB | 42 | 38 | 0.5 | 3 | 9 | 1 |
| Reggie Smith | DB | 41 | 37 | 0.0 | 1 | 4 | 0 |
| Parys Haralson | OLB | 39 | 26 | 4.0 | 0 | 0 | 0 |
| Tarell Brown | CB | 38 | 35 | 0.0 | 1 | 5 | 0 |
| Taylor Mays | S | 35 | 28 | 0.0 | 0 | 2 | 1 |
| Aubrayo Franklin | NT | 35 | 34 | 0.0 | 0 | 1 | 0 |
| Ahmad Brooks | OLB | 29 | 27 | 5.0 | 1 | 2 | 0 |
| Travis LaBoy | OLB | 26 | 19 | 5.0 | 0 | 2 | 1 |
| Isaac Sopoaga | NT | 24 | 16 | 1.5 | 0 | 1 | 0 |
| C.J. Spillman | DB | 18 | 18 | 0.0 | 0 | 0 | 0 |
| Ray McDonald | DE | 17 | 11 | 0.0 | 1 | 2 | 0 |
| Demetric Evans | DE | 15 | 11 | 0.0 | 0 | 1 | 0 |
| Phillip Adams | DB | 11 | 7 | 0.0 | 0 | 1 | 0 |
| Ricky Jean Francois | DT | 11 | 8 | 1.0 | 0 | 1 | 1 |
| Delanie Walker | TE | 10 | 8 | 0.0 | 0 | 0 | 0 |
| Anthony Dixon | RB | 9 | 7 | 0.0 | 0 | 1 | 0 |
| Keaton Kristick | LB | 9 | 8 | 0.0 | 0 | 0 | 0 |
| William James | DB | 8 | 8 | 0.0 | 0 | 1 | 0 |
| Tramaine Brock | DB | 4 | 3 | 0.0 | 0 | 0 | 0 |
| David Baas | C | 4 | 4 | 0.0 | 0 | 0 | 0 |
| Curtis Taylor | DB | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Thaddeus Gibson | DE | 3 | 3 | 0.0 | 0 | 0 | 1 |
| Dominique Zeigler | WR | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Ted Ginn | WR | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Colin Cloherty | TE | 3 | 1 | 0.0 | 0 | 0 | 0 |
| Michael Crabtree | WR | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Chris Maragos | DB | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Adam Snyder | G | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Andy Lee | P | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Frank Gore | RB | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Joe Nedney | K | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Brian Jennings | LS | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Joe Staley | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Troy Smith | QB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Josh Morgan | WR | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Alex Joseph | LB | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Anthony Davis | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Nate Byham | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |