Franchise 77 seasons 609–519–14 all-time 30 playoff trips 5 Super Bowls
2011 players
Passing
| Alex Smith | 445 | 273 | 3,144 | 17 | 5 | 7.1 |
| Colin Kaepernick | 5 | 3 | 35 | 0 | 0 | 7.0 |
| David Akers | 1 | 1 | 14 | 1 | 0 | 14.0 |
Rushing
| Frank Gore | 282 | 1,211 | 8 | 4.3 |
| Kendall Hunter | 112 | 473 | 2 | 4.2 |
| Alex Smith | 52 | 179 | 2 | 3.4 |
| Anthony Dixon | 29 | 87 | 2 | 3.0 |
| Ted Ginn | 8 | 68 | 0 | 8.5 |
| Kyle Williams | 2 | 32 | 0 | 16.0 |
| Bruce Miller | 4 | 8 | 0 | 2.0 |
| Michael Crabtree | 1 | 6 | 0 | 6.0 |
| Delanie Walker | 3 | 5 | 0 | 1.7 |
| Colin Kaepernick | 2 | -2 | 0 | -1.0 |
| Vernon Davis | 2 | -5 | 0 | -2.5 |
| Andy Lee | 1 | -18 | 0 | -18.0 |
Receiving
| Michael Crabtree | 114 | 72 | 874 | 4 | 7.7 |
| Vernon Davis | 95 | 67 | 792 | 6 | 8.3 |
| Kyle Williams | 31 | 20 | 241 | 3 | 7.8 |
| Ted Ginn | 33 | 19 | 220 | 0 | 6.7 |
| Josh Morgan | 20 | 15 | 220 | 1 | 11.0 |
| Delanie Walker | 35 | 19 | 198 | 3 | 5.7 |
| Kendall Hunter | 26 | 16 | 195 | 0 | 7.5 |
| Braylon Edwards | 34 | 15 | 181 | 0 | 5.3 |
| Frank Gore | 31 | 17 | 114 | 0 | 3.7 |
| Bruce Miller | 15 | 11 | 83 | 1 | 5.5 |
| Justin Peelle | 4 | 1 | 19 | 0 | 4.8 |
| Isaac Sopoaga | 1 | 1 | 18 | 0 | 18.0 |
| Joe Staley | 1 | 1 | 17 | 0 | 17.0 |
| Brett Swain | 7 | 2 | 15 | 0 | 2.1 |
| Anthony Dixon | 1 | 1 | 6 | 0 | 6.0 |
Defense
| NaVorro Bowman | MLB | 133 | 101 | 2.0 | 0 | 8 | 0 |
| Patrick Willis | ILB | 89 | 66 | 2.0 | 1 | 12 | 4 |
| Dashon Goldson | DB | 64 | 52 | 0.0 | 6 | 9 | 1 |
| Donte Whitner | S | 58 | 45 | 0.0 | 2 | 10 | 1 |
| Justin Smith | DE | 51 | 38 | 7.5 | 0 | 2 | 3 |
| Ahmad Brooks | OLB | 44 | 29 | 7.0 | 0 | 3 | 1 |
| Carlos Rogers | CB | 41 | 38 | 0.0 | 6 | 18 | 0 |
| Larry Grant | LB | 38 | 29 | 2.0 | 0 | 5 | 1 |
| Tarell Brown | CB | 37 | 33 | 0.0 | 4 | 15 | 0 |
| Aldon Smith | DE | 37 | 31 | 14.0 | 0 | 4 | 2 |
| Chris Culliver | DB | 33 | 31 | 0.0 | 1 | 7 | 0 |
| Ray McDonald | DE | 30 | 20 | 5.5 | 0 | 2 | 2 |
| Parys Haralson | OLB | 29 | 23 | 2.0 | 0 | 0 | 3 |
| Isaac Sopoaga | NT | 23 | 12 | 0.0 | 0 | 1 | 0 |
| C.J. Spillman | DB | 17 | 16 | 0.0 | 0 | 0 | 0 |
| Reggie Smith | DB | 14 | 14 | 0.0 | 1 | 3 | 0 |
| Ricky Jean Francois | DT | 14 | 11 | 0.0 | 0 | 2 | 0 |
| Tavares Gooden | LB | 10 | 10 | 0.0 | 0 | 0 | 1 |
| Blake Costanzo | OLB | 10 | 9 | 0.0 | 0 | 0 | 0 |
| Madieu Williams | FS | 9 | 6 | 0.0 | 0 | 0 | 0 |
| Delanie Walker | TE | 8 | 7 | 0.0 | 0 | 0 | 0 |
| Colin Jones | S | 6 | 6 | 0.0 | 0 | 0 | 0 |
| Bruce Miller | FB | 6 | 4 | 0.0 | 0 | 0 | 0 |
| Anthony Dixon | RB | 6 | 6 | 0.0 | 0 | 0 | 0 |
| Tramaine Brock | DB | 5 | 5 | 0.0 | 2 | 4 | 0 |
| Shawntae Spencer | CB | 5 | 4 | 0.0 | 0 | 1 | 0 |
| Demarcus Dobbs | DE | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Will Tukuafu | FB | 2 | 2 | 0.0 | 0 | 0 | 0 |
| David Akers | K | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Brian Jennings | LS | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Joe Staley | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Frank Gore | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Alex Smith | QB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Ted Ginn | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Adam Snyder | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Mike Iupati | G | 1 | 1 | 0.0 | 0 | 0 | 0 |