Franchise 77 seasons 609–519–14 all-time 30 playoff trips 5 Super Bowls
2015 players
Passing
| Blaine Gabbert | 282 | 178 | 2,031 | 10 | 7 | 7.2 |
| Colin Kaepernick | 244 | 144 | 1,615 | 6 | 5 | 6.6 |
Rushing
| Carlos Hyde | 115 | 470 | 3 | 4.1 |
| Shaun Draughn | 78 | 273 | 1 | 3.5 |
| Colin Kaepernick | 45 | 256 | 1 | 5.7 |
| DuJuan Harris | 48 | 189 | 0 | 3.9 |
| Blaine Gabbert | 32 | 185 | 1 | 5.8 |
| Mike Davis | 35 | 58 | 0 | 1.7 |
| Jarryd Hayne | 17 | 52 | 0 | 3.1 |
| Kendall Gaskins | 16 | 38 | 0 | 2.4 |
| Reggie Bush | 8 | 28 | 0 | 3.5 |
| Bruce Miller | 6 | 14 | 1 | 2.3 |
| Bruce Ellington | 1 | 7 | 0 | 7.0 |
| Quinton Patton | 1 | 5 | 0 | 5.0 |
Receiving
| Anquan Boldin | 111 | 69 | 789 | 4 | 7.1 |
| Torrey Smith | 62 | 33 | 663 | 4 | 10.7 |
| Quinton Patton | 57 | 30 | 394 | 1 | 6.9 |
| Vance McDonald | 46 | 30 | 326 | 3 | 7.1 |
| Blake Bell | 25 | 15 | 186 | 0 | 7.4 |
| Garrett Celek | 28 | 19 | 186 | 3 | 6.6 |
| Shaun Draughn | 35 | 27 | 176 | 0 | 5.0 |
| Bruce Ellington | 19 | 13 | 153 | 0 | 8.1 |
| Bruce Miller | 14 | 10 | 135 | 0 | 9.6 |
| DuJuan Harris | 14 | 9 | 97 | 0 | 6.9 |
| Kendall Gaskins | 10 | 8 | 69 | 0 | 6.9 |
| Jerome Simpson | 19 | 5 | 54 | 1 | 2.8 |
| Carlos Hyde | 15 | 11 | 53 | 0 | 3.5 |
| Mike Davis | 13 | 7 | 38 | 0 | 2.9 |
| Jarryd Hayne | 7 | 6 | 27 | 0 | 3.9 |
| Reggie Bush | 10 | 4 | 19 | 0 | 1.9 |
| DeAndrew White | 2 | 2 | 18 | 0 | 9.0 |
| Brian Leonhardt | 1 | 1 | 4 | 0 | 4.0 |
Defense
| NaVorro Bowman | MLB | 137 | 99 | 2.5 | 0 | 2 | 1 |
| Michael Wilhoite | OLB | 70 | 47 | 0.0 | 1 | 1 | 0 |
| Eric Reid | S | 64 | 53 | 1.0 | 0 | 7 | 1 |
| Kenneth Acker | CB | 63 | 53 | 0.0 | 3 | 8 | 0 |
| Gerald Hodges | LB | 63 | 46 | 0.0 | 0 | 1 | 0 |
| Jaquiski Tartt | S | 60 | 47 | 2.0 | 1 | 3 | 1 |
| Ian Williams | NT | 57 | 37 | 1.0 | 0 | 1 | 1 |
| Quinton Dial | DT | 55 | 28 | 2.5 | 0 | 1 | 0 |
| Jimmie Ward | SAF | 54 | 45 | 1.0 | 1 | 6 | 0 |
| Tramaine Brock | DB | 48 | 40 | 0.0 | 3 | 11 | 0 |
| Ahmad Brooks | OLB | 39 | 25 | 6.5 | 0 | 1 | 0 |
| Antoine Bethea | FS | 36 | 24 | 1.0 | 0 | 2 | 0 |
| Aaron Lynch | OLB | 35 | 27 | 6.5 | 0 | 3 | 0 |
| Dontae Johnson | DB | 30 | 27 | 0.0 | 0 | 5 | 0 |
| Tank Carradine | DE | 21 | 13 | 1.0 | 0 | 0 | 1 |
| Ray-Ray Armstrong | LB | 20 | 17 | 1.0 | 0 | 0 | 0 |
| Arik Armstead | DT | 19 | 14 | 2.0 | 0 | 0 | 0 |
| Nick Bellore | LB | 15 | 10 | 0.0 | 0 | 0 | 0 |
| Mike Purcell | NT | 14 | 10 | 1.0 | 0 | 0 | 0 |
| Glenn Dorsey | NT | 13 | 11 | 0.0 | 0 | 0 | 0 |
| Eli Harold | LB | 13 | 7 | 0.0 | 0 | 0 | 0 |
| Marcus Cromartie | DB | 12 | 10 | 0.0 | 0 | 2 | 0 |
| Tony Jerod-Eddie | DE | 12 | 9 | 0.0 | 0 | 4 | 0 |
| Corey Lemonier | OLB | 12 | 8 | 0.0 | 0 | 0 | 0 |
| Bruce Miller | FB | 8 | 8 | 0.0 | 0 | 0 | 0 |
| Keith Reaser | CB | 7 | 6 | 0.0 | 0 | 0 | 0 |
| L.J. McCray | DB | 5 | 4 | 0.0 | 0 | 0 | 0 |
| Kyle Nelson | LS | 5 | 4 | 0.0 | 0 | 0 | 0 |
| Vance McDonald | TE | 4 | 4 | 0.0 | 0 | 0 | 0 |
| Quinton Patton | WR | 4 | 3 | 0.0 | 0 | 0 | 0 |
| Shayne Skov | LB | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Bradley Pinion | P | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Shaun Draughn | RB | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Anquan Boldin | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Jarryd Hayne | RB | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Kendall Gaskins | RB | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Joe Staley | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Blaine Gabbert | QB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Torrey Smith | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Garrett Celek | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Chris Davis | CB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Bruce Ellington | WR | 1 | 1 | 0.0 | 0 | 1 | 0 |
| Marcus Martin | C | 1 | 1 | 0.0 | 0 | 0 | 0 |
| DeAndrew White | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Mike Davis | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |