Franchise 77 seasons 609–519–14 all-time 30 playoff trips 5 Super Bowls
2019 players
Passing
| Jimmy Garoppolo | 476 | 329 | 3,978 | 27 | 13 | 8.4 |
| Emmanuel Sanders | 1 | 1 | 35 | 1 | 0 | 35.0 |
| Dante Pettis | 1 | 1 | 16 | 0 | 0 | 16.0 |
Rushing
| Raheem Mostert | 137 | 772 | 8 | 5.6 |
| Matt Breida | 123 | 623 | 1 | 5.1 |
| Tevin Coleman | 137 | 544 | 6 | 4.0 |
| Deebo Samuel Sr. | 14 | 159 | 3 | 11.4 |
| Jeff Wilson | 27 | 105 | 4 | 3.9 |
| Jimmy Garoppolo | 46 | 62 | 1 | 1.3 |
| George Kittle | 5 | 22 | 0 | 4.4 |
| Marquise Goodwin | 1 | 15 | 0 | 15.0 |
| Kyle Juszczyk | 3 | 7 | 0 | 2.3 |
| Richie James | 2 | -1 | 0 | -0.5 |
| Nick Mullens | 3 | -3 | 0 | -1.0 |
Receiving
| George Kittle | 107 | 85 | 1,053 | 5 | 9.8 |
| Emmanuel Sanders | 97 | 66 | 869 | 5 | 9.0 |
| Deebo Samuel Sr. | 81 | 57 | 802 | 3 | 9.9 |
| Kendrick Bourne | 44 | 30 | 358 | 5 | 8.1 |
| Kyle Juszczyk | 24 | 20 | 239 | 1 | 10.0 |
| Marquise Goodwin | 21 | 12 | 186 | 1 | 8.9 |
| Raheem Mostert | 22 | 14 | 180 | 2 | 8.2 |
| Tevin Coleman | 30 | 21 | 180 | 1 | 6.0 |
| Richie James | 10 | 6 | 165 | 1 | 16.5 |
| Matt Breida | 22 | 19 | 120 | 1 | 5.5 |
| Dante Pettis | 24 | 11 | 109 | 2 | 4.5 |
| Ross Dwelley | 22 | 15 | 91 | 2 | 4.1 |
| Jeff Wilson | 5 | 3 | 34 | 1 | 6.8 |
| Levine Toilolo | 2 | 2 | 10 | 0 | 5.0 |