Franchise 77 seasons 609–519–14 all-time 30 playoff trips 5 Super Bowls
2022 players
Passing
| Jimmy Garoppolo | 308 | 207 | 2,437 | 16 | 4 | 7.9 |
| Brock Purdy | 170 | 114 | 1,374 | 13 | 4 | 8.1 |
| Trey Lance | 31 | 15 | 194 | 0 | 1 | 6.3 |
| Christian McCaffrey | 1 | 1 | 34 | 1 | 0 | 34.0 |
| Josh Johnson | 2 | 1 | 10 | 0 | 0 | 5.0 |
Rushing
| Christian McCaffrey | 244 | 1,139 | 8 | 4.7 |
| Elijah Mitchell | 45 | 279 | 2 | 6.2 |
| Jordan Mason | 43 | 258 | 1 | 6.0 |
| Deebo Samuel Sr. | 42 | 232 | 3 | 5.5 |
| Tyrion Davis-Price | 34 | 99 | 0 | 2.9 |
| Ray-Ray McCloud | 4 | 78 | 1 | 19.5 |
| Trey Lance | 16 | 67 | 0 | 4.2 |
| Jimmy Garoppolo | 23 | 33 | 2 | 1.4 |
| Kyle Juszczyk | 7 | 26 | 1 | 3.7 |
| Tevin Coleman | 12 | 26 | 1 | 2.2 |
| Brandon Aiyuk | 2 | 23 | 0 | 11.5 |
| Brock Purdy | 22 | 13 | 1 | 0.6 |
| Danny Gray | 1 | 9 | 0 | 9.0 |
| Josh Johnson | 2 | 3 | 0 | 1.5 |
Receiving
| Brandon Aiyuk | 114 | 78 | 1,015 | 8 | 8.9 |
| George Kittle | 86 | 60 | 765 | 11 | 8.9 |
| Christian McCaffrey | 108 | 85 | 741 | 5 | 6.9 |
| Deebo Samuel Sr. | 94 | 56 | 632 | 2 | 6.7 |
| Jauan Jennings | 56 | 35 | 416 | 1 | 7.4 |
| Ray-Ray McCloud | 25 | 14 | 243 | 1 | 9.7 |
| Kyle Juszczyk | 23 | 19 | 200 | 1 | 8.7 |
| Ross Dwelley | 5 | 3 | 105 | 1 | 21.0 |
| Tyler Kroft | 5 | 4 | 57 | 0 | 11.4 |
| Tevin Coleman | 3 | 3 | 44 | 1 | 14.7 |
| Danny Gray | 7 | 1 | 10 | 0 | 1.4 |
| Elijah Mitchell | 4 | 3 | 7 | 0 | 1.8 |