Franchise 77 seasons 609–519–14 all-time 30 playoff trips 5 Super Bowls
2023 players
Passing
| Brock Purdy | 444 | 308 | 4,280 | 31 | 11 | 9.6 |
| Sam Darnold | 46 | 28 | 297 | 2 | 1 | 6.5 |
| Deebo Samuel Sr. | 1 | 0 | 0 | 0 | 0 | 0.0 |
Rushing
| Christian McCaffrey | 272 | 1,459 | 14 | 5.4 |
| Elijah Mitchell | 75 | 281 | 2 | 3.7 |
| Deebo Samuel Sr. | 37 | 225 | 5 | 6.1 |
| Jordan Mason | 40 | 206 | 3 | 5.2 |
| Brock Purdy | 39 | 144 | 2 | 3.7 |
| Ray-Ray McCloud | 3 | 30 | 0 | 10.0 |
| Tyrion Davis-Price | 6 | 21 | 0 | 3.5 |
| Sam Darnold | 21 | 15 | 1 | 0.7 |
| Kyle Juszczyk | 5 | 6 | 0 | 1.2 |
| George Kittle | 1 | 2 | 0 | 2.0 |
Receiving
| Brandon Aiyuk | 105 | 75 | 1,342 | 7 | 12.8 |
| George Kittle | 90 | 65 | 1,020 | 6 | 11.3 |
| Deebo Samuel Sr. | 89 | 60 | 892 | 7 | 10.0 |
| Christian McCaffrey | 83 | 67 | 564 | 7 | 6.8 |
| Jauan Jennings | 33 | 19 | 265 | 1 | 8.0 |
| Ray-Ray McCloud | 15 | 12 | 135 | 0 | 9.0 |
| Kyle Juszczyk | 17 | 14 | 119 | 2 | 7.0 |
| Chris Conley | 6 | 3 | 69 | 0 | 11.5 |
| Ronnie Bell | 13 | 6 | 68 | 3 | 5.2 |
| Charlie Woerner | 3 | 3 | 32 | 0 | 10.7 |
| Jordan Mason | 4 | 3 | 31 | 0 | 7.8 |
| Willie Snead | 3 | 2 | 14 | 0 | 4.7 |
| Elijah Mitchell | 8 | 6 | 14 | 0 | 1.8 |
| Ross Dwelley | 2 | 1 | 12 | 0 | 6.0 |