Franchise 77 seasons 609–519–14 all-time 30 playoff trips 5 Super Bowls
2024 players
Passing
| Brock Purdy | 455 | 300 | 3,864 | 20 | 12 | 8.5 |
| Joshua Dobbs | 47 | 32 | 361 | 2 | 2 | 7.7 |
| Brandon Allen | 30 | 17 | 199 | 1 | 2 | 6.6 |
| Ricky Pearsall | 1 | 0 | 0 | 0 | 0 | 0.0 |
Rushing
| Jordan Mason | 153 | 789 | 3 | 5.2 |
| Isaac Guerendo | 84 | 420 | 4 | 5.0 |
| Brock Purdy | 66 | 323 | 5 | 4.9 |
| Christian McCaffrey | 50 | 202 | 0 | 4.0 |
| Patrick Taylor | 39 | 183 | 1 | 4.7 |
| Deebo Samuel Sr. | 42 | 136 | 1 | 3.2 |
| Ricky Pearsall | 3 | 45 | 0 | 15.0 |
| Kyle Juszczyk | 5 | 26 | 1 | 5.2 |
| Joshua Dobbs | 9 | 24 | 2 | 2.7 |
| Jacob Cowing | 1 | 7 | 0 | 7.0 |
| Brandon Allen | 3 | 4 | 0 | 1.3 |
| Ke'Shawn Vaughn | 2 | 4 | 0 | 2.0 |
Receiving
| George Kittle | 94 | 78 | 1,106 | 8 | 11.8 |
| Jauan Jennings | 113 | 77 | 975 | 6 | 8.6 |
| Deebo Samuel Sr. | 81 | 51 | 670 | 3 | 8.3 |
| Ricky Pearsall | 46 | 31 | 400 | 3 | 8.7 |
| Brandon Aiyuk | 47 | 25 | 374 | 0 | 8.0 |
| Kyle Juszczyk | 31 | 19 | 200 | 2 | 6.5 |
| Isaac Guerendo | 16 | 15 | 152 | 0 | 9.5 |
| Christian McCaffrey | 19 | 15 | 146 | 0 | 7.7 |
| Eric Saubert | 14 | 11 | 97 | 1 | 6.9 |
| Jordan Mason | 14 | 11 | 91 | 0 | 6.5 |
| Jacob Cowing | 6 | 4 | 80 | 0 | 13.3 |
| Chris Conley | 12 | 6 | 76 | 0 | 6.3 |
| Patrick Taylor | 11 | 3 | 25 | 0 | 2.3 |
| Ronnie Bell | 6 | 2 | 22 | 0 | 3.7 |
| Trent Taylor | 1 | 1 | 11 | 0 | 11.0 |