Franchise 77 seasons 609–519–14 all-time 30 playoff trips 5 Super Bowls
2025 players
Passing
| Brock Purdy | 284 | 197 | 2,167 | 20 | 10 | 7.6 |
| Mac Jones | 289 | 201 | 2,151 | 13 | 6 | 7.4 |
| Christian McCaffrey | 1 | 0 | 0 | 0 | 0 | 0.0 |
Rushing
| Christian McCaffrey | 311 | 1,202 | 10 | 3.9 |
| Brian Robinson | 92 | 400 | 2 | 4.3 |
| Brock Purdy | 33 | 147 | 3 | 4.5 |
| Mac Jones | 36 | 60 | 0 | 1.7 |
| Skyy Moore | 2 | 11 | 0 | 5.5 |
| Demarcus Robinson | 1 | 6 | 0 | 6.0 |
| Adrian Martinez | 1 | -1 | 0 | -1.0 |
| Ricky Pearsall | 2 | -2 | 0 | -1.0 |
| Kyle Juszczyk | 2 | -3 | 0 | -1.5 |
| George Kittle | 1 | -3 | 0 | -3.0 |
Receiving
| Christian McCaffrey | 129 | 102 | 924 | 7 | 7.2 |
| Jauan Jennings | 90 | 55 | 643 | 9 | 7.1 |
| George Kittle | 69 | 57 | 628 | 7 | 9.1 |
| Kendrick Bourne | 53 | 37 | 551 | 0 | 10.4 |
| Ricky Pearsall | 53 | 36 | 528 | 0 | 10.0 |
| Jake Tonges | 46 | 34 | 293 | 5 | 6.4 |
| Demarcus Robinson | 35 | 22 | 276 | 1 | 7.9 |
| Kyle Juszczyk | 28 | 24 | 213 | 2 | 7.6 |
| Skyy Moore | 7 | 5 | 87 | 0 | 12.4 |
| Luke Farrell | 14 | 11 | 85 | 2 | 6.1 |
| Jordan Watkins | 3 | 2 | 26 | 0 | 8.7 |
| Brian Robinson | 12 | 8 | 25 | 0 | 2.1 |
| Connor Colby | 1 | 1 | -1 | 0 | -1.0 |
Defense
| Dee Winters | LB | 98 | 64 | 0.0 | 1 | 5 | 0 |
| Tatum Bethune | LB | 92 | 37 | 1.0 | 0 | 4 | 0 |
| Upton Stout | CB | 82 | 43 | 1.0 | 0 | 5 | 1 |
| Ji'Ayir Brown | SAF | 75 | 43 | 0.0 | 2 | 6 | 1 |
| Malik Mustapha | SAF | 74 | 42 | 0.0 | 1 | 3 | 0 |
| Renardo Green | CB | 60 | 36 | 0.0 | 0 | 10 | 0 |
| Deommodore Lenoir | CB | 58 | 36 | 0.0 | 2 | 5 | 0 |
| Marques Sigle | SAF | 52 | 28 | 0.0 | 0 | 2 | 0 |
| Fred Warner | MLB | 50 | 27 | 0.0 | 0 | 3 | 2 |
| Jason Pinnock | SAF | 41 | 27 | 0.0 | 0 | 0 | 0 |
| Curtis Robinson | LB | 41 | 18 | 0.0 | 0 | 1 | 0 |
| Sam Okuayinonu | DT | 39 | 23 | 3.0 | 0 | 0 | 1 |
| Luke Gifford | LB | 35 | 12 | 0.0 | 0 | 1 | 0 |
| Jordan Elliott | DT | 31 | 8 | 0.0 | 0 | 1 | 0 |
| Bryce Huff | DE | 29 | 13 | 4.0 | 0 | 1 | 2 |
| Kalia Davis | DT | 28 | 10 | 0.5 | 0 | 3 | 0 |
| Darrell Luter Jr. | CB | 27 | 16 | 0.0 | 0 | 1 | 0 |
| Clelin Ferrell | DE | 25 | 13 | 4.0 | 0 | 0 | 0 |
| CJ West | DT | 20 | 11 | 1.0 | 0 | 0 | 0 |
| Mykel Williams | DE | 19 | 10 | 1.0 | 0 | 0 | 0 |
| Keion White | DE | 17 | 6 | 1.5 | 0 | 1 | 0 |
| Nick Bosa | DE | 17 | 9 | 2.0 | 0 | 0 | 2 |
| Alfred Collins | DT | 17 | 4 | 1.0 | 0 | 2 | 2 |
| Siran Neal | DB | 17 | 6 | 0.0 | 0 | 0 | 0 |
| Robert Beal Jr. | DE | 14 | 3 | 0.0 | 0 | 0 | 0 |
| Nick Martin | LB | 11 | 8 | 0.0 | 0 | 0 | 1 |
| Chase Lucas | CB | 9 | 6 | 0.0 | 0 | 1 | 0 |
| Garret Wallow | LB | 9 | 2 | 0.0 | 0 | 0 | 0 |
| Yetur Gross-Matos | DE | 8 | 3 | 0.0 | 0 | 1 | 0 |
| Jake Tonges | TE | 8 | 5 | 0.0 | 0 | 0 | 0 |
| Luke Farrell | TE | 7 | 3 | 0.0 | 0 | 0 | 0 |
| Eric Kendricks | MLB | 6 | 3 | 0.0 | 0 | 0 | 0 |
| Brayden Willis | TE | 6 | 3 | 0.0 | 0 | 0 | 0 |
| Isaac Guerendo | RB | 4 | 2 | 0.0 | 0 | 0 | 1 |
| Christian McCaffrey | RB | 4 | 3 | 0.0 | 0 | 0 | 0 |
| Colton McKivitz | OT | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Malik Turner | WR | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Trent Williams | OT | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Kyle Juszczyk | FB | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Jon Weeks | LS | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Kevin Givens | DT | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Jauan Jennings | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| George Kittle | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Eli Apple | CB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Mac Jones | QB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Spencer Burford | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Jalen Graham | LB | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Dominick Puni | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Ricky Pearsall | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |