Regular season
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating | Drop% | BadTh% | OnTgt% | Press% | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2001 | SD | 1 | 27 | 15 | 55.6 | 221 | 1 | 0 | 2 | 8.2 | 94.8 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2002 | SD | 16 | 526 | 320 | 60.8 | 3284 | 17 | 16 | 24 | 6.2 | 76.9 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2003 | LAC | 11 | 356 | 205 | 57.6 | 2108 | 11 | 15 | 21 | 5.9 | 67.5 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2004 | LAC | 15 | 400 | 262 | 65.5 | 3159 | 27 | 7 | 17 | 7.9 | 104.8 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2005 | LAC | 16 | 500 | 323 | 64.6 | 3576 | 24 | 15 | 27 | 7.2 | 89.2 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2006 | NO | 16 | 555 | 357 | 64.3 | 4424 | 26 | 11 | 18 | 8.0 | 96.3 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2007 | NO | 16 | 655 | 443 | 67.6 | 4428 | 28 | 18 | 15 | 6.8 | 89.4 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2008 | NO | 16 | 635 | 413 | 65.0 | 5069 | 34 | 17 | 13 | 8.0 | 96.2 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2009 | NO | 15 | 514 | 363 | 70.6 | 4388 | 34 | 11 | 20 | 8.5 | 109.6 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2010 | NO | 16 | 658 | 448 | 68.1 | 4620 | 33 | 22 | 26 | 7.0 | 90.9 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2011 | NO | 16 | 660 | 471 | 71.4 | 5535 | 46 | 14 | 24 | 8.4 | 110.9 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2012 | NO | 16 | 670 | 422 | 63.0 | 5177 | 43 | 19 | 26 | 7.7 | 96.3 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2013 | NO | 16 | 650 | 446 | 68.6 | 5162 | 39 | 12 | 37 | 7.9 | 104.7 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2014 | NO | 16 | 659 | 456 | 69.2 | 4952 | 33 | 17 | 29 | 7.5 | 97.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2015 | NO | 15 | 627 | 428 | 68.3 | 4870 | 32 | 11 | 31 | 7.8 | 101.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2016 | NO | 16 | 673 | 471 | 70.0 | 5208 | 37 | 15 | 27 | 7.7 | 101.7 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2017 | NO | 16 | 536 | 386 | 72.0 | 4334 | 23 | 8 | 20 | 8.1 | 103.9 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2018 | NO | 15 | 489 | 364 | 74.4 | 3992 | 32 | 5 | 17 | 8.2 | 115.7 | 4.6 | 10.3 | 0.0 | 16.5 | 2.4 |
| 2019 | NO | 11 | 378 | 281 | 74.3 | 2979 | 27 | 4 | 12 | 7.9 | 116.3 | 3.6 | 10.7 | 84.1 | 13.8 | 2.3 |
| 2020 | NO | 12 | 390 | 275 | 70.5 | 2942 | 24 | 6 | 13 | 7.5 | 106.4 | 5.5 | 13.4 | 80.8 | 14.6 | 2.4 |