Regular season and playoffs
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2001 | SD | 1 | 27 | 15 | 55.6 | 221 | 1 | 0 | 2 | 8.2 | 94.8 |
| 2002 | SD | 16 | 526 | 320 | 60.8 | 3284 | 17 | 16 | 24 | 6.2 | 76.9 |
| 2003 | LAC | 11 | 356 | 205 | 57.6 | 2108 | 11 | 15 | 21 | 5.9 | 67.5 |
| 2004 | LAC | 16 | 442 | 293 | 66.3 | 3478 | 29 | 8 | 19 | 7.9 | 104.4 |
| 2005 | LAC | 16 | 500 | 323 | 64.6 | 3576 | 24 | 15 | 27 | 7.2 | 89.2 |
| 2006 | NO | 18 | 636 | 404 | 63.5 | 5021 | 29 | 12 | 24 | 7.9 | 95.3 |
| 2007 | NO | 16 | 655 | 443 | 67.6 | 4428 | 28 | 18 | 15 | 6.8 | 89.4 |
| 2008 | NO | 16 | 635 | 413 | 65.0 | 5069 | 34 | 17 | 13 | 8.0 | 96.2 |
| 2009 | NO | 18 | 616 | 435 | 70.6 | 5120 | 42 | 11 | 22 | 8.3 | 110.8 |
| 2010 | NO | 17 | 718 | 487 | 67.8 | 5024 | 35 | 22 | 27 | 7.0 | 91.2 |
| 2011 | NO | 18 | 766 | 544 | 71.0 | 6463 | 53 | 16 | 29 | 8.4 | 110.8 |
| 2012 | NO | 16 | 670 | 422 | 63.0 | 5177 | 43 | 19 | 26 | 7.7 | 96.3 |
| 2013 | NO | 18 | 723 | 490 | 67.8 | 5721 | 41 | 14 | 40 | 7.9 | 102.4 |
| 2014 | NO | 16 | 659 | 456 | 69.2 | 4952 | 33 | 17 | 29 | 7.5 | 97.0 |
| 2015 | NO | 15 | 627 | 428 | 68.3 | 4870 | 32 | 11 | 31 | 7.8 | 101.0 |
| 2016 | NO | 16 | 673 | 471 | 70.0 | 5208 | 37 | 15 | 27 | 7.7 | 101.7 |
| 2017 | NO | 18 | 609 | 434 | 71.3 | 5004 | 28 | 11 | 23 | 8.2 | 103.5 |
| 2018 | NO | 17 | 567 | 418 | 73.7 | 4542 | 36 | 7 | 21 | 8.0 | 112.9 |
| 2019 | NO | 12 | 411 | 307 | 74.7 | 3187 | 28 | 5 | 15 | 7.8 | 114.3 |
| 2020 | NO | 14 | 463 | 322 | 69.5 | 3341 | 27 | 9 | 13 | 7.2 | 101.4 |